Persistence of Diplococcus pneumoniae after influenza virus infection in Macaca mulatta.
نویسندگان
چکیده
Exposure of monkeys to aerosols of influenza virus followed later by aerosols of Diplococcus pneumoniae resulted in persistence of the bacteria in the upper respiratory tract for an average of 28 days. Examination of selected tissues for pneumococci revealed that pneumococci were widely disseminated throughout the respiratory tract at 3 and 7 days after exposure, but were cleared from lower respiratory tissues and were found mainly in tonsils, oropharynx, and posterior nasopharynx after 14 days.
منابع مشابه
Alterations in thyroid hormone economy during acute infection with Diplococcus pneumoniae in the rhesus monkey.
In order to study the alterations in thyroid hormone economy that accompany an acute bacterial infection, rhesus monkeys were inoculated i.v. with a virulent Diplococcus pneumoniae culture containing approximately 10(8) organisms per dose. This was found to produce a well-defined febrile illness followed in most instances by spontaneous recovery, thereby permitting sequential observations to be...
متن کاملReactions of Monkeys to Experimentally Induced Influenza Virus a Infection
1. Macaca mulatta monkeys on a normal diet have proved resistant to intranasal but not to intratracheal inoculation of influenza virus. 2. Neutralizing antibodies appeared 8 to 10 days after inoculation with either living or heat-inactivated virus. The antibodies were noted to be still present as long as 9 months after infection with living virus. 3. A specific granulopenic leucopenia character...
متن کاملEarly blood profiles of virus infection in a monkey model for Lassa fever.
Acute arenavirus disease in primates, like Lassa hemorrhagic fever in humans, begins with flu-like symptoms and leads to death approximately 2 weeks after infection. Our goal was to identify molecular changes in blood that are related to disease progression. Rhesus macaques (Macaca mulatta) infected intravenously with a lethal dose of lymphocytic choriomeningitis virus (LCMV) provide a model fo...
متن کاملExperimental Infection of Macaques with a Wild Water Bird-Derived Highly Pathogenic Avian Influenza Virus (H5N1)
Highly pathogenic avian influenza virus (HPAIV) continues to threaten human health. Non-human primate infection models of human influenza are desired. To establish an animal infection model with more natural transmission and to determine the pathogenicity of HPAIV isolated from a wild water bird in primates, we administered a Japanese isolate of HPAIV (A/whooper swan/Hokkaido/1/2008, H5N1 clade...
متن کاملInfluence of Naturally Occurring Simian Foamy Viruses (SFVs) on SIV Disease Progression in the Rhesus Macaque (Macaca mulatta) Model
We have investigated the influence of naturally occurring simian foamy viruses (SFVs) on simian immunodeficiency virus (SIV) infection and disease in Indian rhesus macaques. Animals were divided into two groups based upon presence or absence of SFV; in each group, eight monkeys were injected with SIV(mac239) virus obtained from a molecular clone and four were injected with medium. Blood was col...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Infection and immunity
دوره 10 2 شماره
صفحات -
تاریخ انتشار 1974